Chronic  pain that does not go away even after taking medication and getting enough rest.

If the pain worsens over time, consult a doctor, as it could be a sign of a more serious condition, such as bone  cancer (bone pain or fractures), brain tumors (causing persistent headaches, nausea, and vision problems), ovarian or colorectal cancer (causing pelvic or abdominal pain), or lung cancer (chest pain).

unusual lumps or bumps

Lumps and growths on the skin are common. However, if the lumps get bigger, redder, and more painful, last for more than two weeks, are hard and don’t move, or appear on the breasts or nipples, consult your doctor.